Publications
Publications
Listed by year, * denotes joint first authorship
Ansell, T.B., Healey, M., Coupland, C., Sansom, M.S.P., Siebold, C. (2023). Mapping Structural and Dynamic Divergence Across the MBOAT family. bioRxiv
Ansell, T.B., Song, W., Coupland, C.E., Carrique, L., Corey, R.A., Duncan, A.L., Cassidy, C.K., Geurtz, M.M.G., Rassmussen, T., Ward, A.B., Siebold, C., Stansfeld, P.J., Sansom, M.S.P. (2023). LipIDens: Simulation Assisted Interpretation of Lipid Densities in Cryo-EM Structures of Membrane Proteins. Nat. Comms., 14, 7774
Ansell, T.B., Corey, R.A., Viti, L.V., Kinnebrew, M., Rohatgi, R., Siebold, C., Sansom, M.S.P. (2023). The Energetics and Ion Coupling of Cholesterol Transport through Patched1. Sci. Advances, 9, eadh1609
*Coupland, C., Ansell, T.B., Sansom, M.S.P., Siebold, C. (2023). Rocking the MBOAT: Structural Insights into the Membrane bound O-acyltransferase family. Curr. Opin. Struc. Biol., 80, 102589
McGlone, E.R., Ansell, T.B., Dunsterville, C., Song, W., Carling, D., Tomas, A., Bloom, S.R., Sansom, M.S.P., Tan, T., Jones, B. (2022). Hepatocyte cholesterol content modulates glucagon receptor signalling. Molecular Metabolism, 63, 101530
Kinnebrew, M., Woolley, R.E., Ansell, T.B., Byrne, E.F.X., Frigui, S., Luchetti, G., Sircar, R., Nachtergaele, S., Mydock-McGrane, L., Krishnan, K., Newstead, S., Sansom, M.S.P., Covey, D.F., Siebold, C. and Rohatgi, R. (2022). Patched1 regulates Smoothened by controlling sterol binding to its extracellular cysteine-rich domain. Sci. Advances, 8, eabm5563
Song, W., Corey R.A., Ansell, T.B., Cassidy, C.K., Horrell, M.R., Duncan, A.L., Stansfeld, P.J., Sansom, M.S.P. (2022). PyLipID: A Python Package for Analysis of Protein-Lipid Interactions from Molecular Dynamics Simulations. J. Chem. Theory Comput., 18, 2, 1188-1201
*Coupland, C.E., Andrei, S.A., Ansell, T.B., Carrique, L., Kumar, P., Sefer, L., Schwab, R.A., Byrne, E.F.X., Pardon, E., Steyaert, J., Magee, A. I., Lanyon-Hogg, T., Sansom, M.S.P., Tate, E.W., Siebold, C. (2021). Structure, mechanism, and inhibition of Hedgehog acyltransferase. Mol. Cell., 81, 24, 5025-5038
Ansell, T.B., Curran, L., Horrell, M.R., Pipatpolkai, T., Letham, S.C., Song, W., Siebold, C., Stansfeld, P.J., Sansom, M.S.P., Corey, R.A. (2021). Relative Affinities of Protein-Cholesterol Interactions from Equilibrium Molecular Dynamics Simulations. J. Chem. Theory Comput., 17, 10, 6548-6558
Corey, R.A., Song, W., Duncan, A.L., Ansell, T.B., Sansom, M.S.P., Stansfeld, P.J. (2021). Identification and assessment of cardiolipin interactions with E. coli inner membrane proteins. Sci. Advances, 7, eabh2217
Ansell, T.B., Song, W., Sansom, M.S.P. (2020). The Glycosphingolipid GM3 Modulates Conformational Dynamics of the Glucagon Receptor. Biophys. J., 119, 300- 313
*Rudolf, A.F., Kinnebrew, M., Kowatsch, C., Ansell, T.B., El Omari, K., Bishop, B., Pardon, E., Schwab, R.A., Malinauskas, T., Qian, M., Duman, R., Covey, D.F., Steyaert, J., Wagner, A., Sansom, M.S.P., Rohatgi, R., Siebold, C. (2019). The morphogen Sonic hedgehog inhibits its receptor Patched by a pincer grasp mechanism. Nat. Chem. Biology, 15, 975-982