Publications

Conflitti, P., Lyman, E., Sansom, M.S.P., Hildebrand, P.W., Gutiérrez-de-Terán, H., Carloni, P., Ansell, T.B., Yuan, S., Barth, P., Robinson, A.S., Tate, C.G., Gloriam, D., Grzesiek, S., Eddy, M.T., Prosser, S.,  Limongelli, V. (2025). Functional dynamics of G protein-coupled receptors reveal new routes for drug discovery. Nat. Rev. Drug. Discov, 24, 251-275

Berrios, L., Ansell, T.B., Dahlberg, P.D., Peay, K. (2025). Standardizing experimental approaches to investigate interactions between bacteria and ectomycorrhizal fungi. FEMS Microbiology Reviews, 49, fuae035

Perez, D., Dowlatshahi, D.P., Azaldegui, C.A., Ansell, T.B., Dahlberg, P.D., Moerner, W.E. (2024). Exploring Transient States of PAmKate to Enable Improved Cryogenic Single-Molecule Imaging. J. Am. Chem. Soc., 146, 28707-28716

Berrios, L., Venturini, A.M., Ansell, T.B., Tok, E., Johnson, W., Willing, C.E., Peay, K.G. (2024). Co-inoculations of bacteria and mucorrhizal fungi often drive additive plant growth responses. ISME Communications, 4, ycea104 

Berrios, L., Bogar, G.D., Bogar, L.M., Venturini, A.M., Willing, C.E., Del Rio, A., Ansell, T.B., Zemaitis, K., Velickovic, M., Velickovic, D., Pellitier, P.T., Yeam, J., Hutchinson, C., Bloodsworth, K., Lipton, M.S., Peay, K.G. (2024). Ectomycorrhizal fungi alter soil food webs and the functional potential of bacterial communities. mSystems, 9, e00369-24 

Ansell, T.B., Healey, M., Coupland, C., Sansom, M.S.P., Siebold, C. (2024). Mapping Structural and Dynamic Divergence Across the MBOAT family. Structure, 32, 1011-1022

Ansell, T.B., Song, W., Coupland, C.E., Carrique, L., Corey, R.A., Duncan, A.L., Cassidy, C.K., Geurtz, M.M.G., Rassmussen, T., Ward, A.B., Siebold, C., Stansfeld, P.J., Sansom, M.S.P. (2023). LipIDens: Simulation Assisted Interpretation of Lipid Densities in Cryo-EM Structures of Membrane Proteins. Nat. Comms., 14, 7774

• Accompanying protocol: Implementation of the LipIDens pipeline: assisted interpretation of lipid densities in membrane protein structures using simulations

• GitHub: TBGAnsell/LipIDens

Ansell, T.B., Corey, R.A., Viti, L.V., Kinnebrew, M., Rohatgi, R., Siebold, C., Sansom, M.S.P. (2023). The Energetics and Ion Coupling of Cholesterol Transport through Patched1. Sci. Advances, 9, eadh1609

*Coupland, C., Ansell, T.B., Sansom, M.S.P., Siebold, C. (2023). Rocking the MBOAT: Structural Insights into the Membrane bound O-acyltransferase family. Curr. Opin. Struc. Biol., 80, 102589

McGlone, E.R., Ansell, T.B., Dunsterville, C., Song, W., Carling, D., Tomas, A., Bloom, S.R., Sansom, M.S.P., Tan, T., Jones, B. (2022). Hepatocyte cholesterol content modulates glucagon receptor signalling. Molecular Metabolism, 63, 101530

Kinnebrew, M., Woolley, R.E., Ansell, T.B., Byrne, E.F.X., Frigui, S., Luchetti, G., Sircar, R., Nachtergaele, S., Mydock-McGrane, L., Krishnan, K., Newstead, S., Sansom, M.S.P., Covey, D.F., Siebold, C. and Rohatgi, R. (2022). Patched1 regulates Smoothened by controlling sterol binding to its extracellular cysteine-rich domain. Sci. Advances, 8, eabm5563

Song, W., Corey R.A., Ansell, T.B., Cassidy, C.K., Horrell, M.R., Duncan, A.L., Stansfeld, P.J., Sansom, M.S.P. (2022). PyLipID: A Python Package for Analysis of Protein-Lipid Interactions from Molecular Dynamics Simulations. J. Chem. Theory Comput., 18, 2, 1188-1201

*Coupland, C.E., Andrei, S.A., Ansell, T.B., Carrique, L., Kumar, P., Sefer, L., Schwab, R.A., Byrne, E.F.X., Pardon, E., Steyaert, J., Magee, A. I., Lanyon-Hogg, T., Sansom, M.S.P., Tate, E.W., Siebold, C. (2021). Structure, mechanism, and inhibition of Hedgehog acyltransferase. Mol. Cell., 81, 24, 5025-5038

Ansell, T.B., Curran, L., Horrell, M.R., Pipatpolkai, T., Letham, S.C., Song, W., Siebold, C., Stansfeld, P.J., Sansom, M.S.P., Corey, R.A. (2021). Relative Affinities of Protein-Cholesterol Interactions from Equilibrium Molecular Dynamics Simulations. J. Chem. Theory Comput., 17, 10, 6548-6558

Corey, R.A., Song, W., Duncan, A.L., Ansell, T.B., Sansom, M.S.P., Stansfeld, P.J. (2021). Identification and assessment of cardiolipin interactions with E. coli inner membrane proteins. Sci. Advances, 7, eabh2217

Ansell, T.B., Song, W., Sansom, M.S.P. (2020). The Glycosphingolipid GM3 Modulates Conformational Dynamics of the Glucagon Receptor. Biophys. J., 119, 300- 313

*Rudolf, A.F., Kinnebrew, M., Kowatsch, C., Ansell, T.B., El Omari, K., Bishop, B., Pardon, E., Schwab, R.A., Malinauskas, T., Qian, M., Duman, R., Covey, D.F., Steyaert, J., Wagner, A., Sansom, M.S.P., Rohatgi, R., Siebold, C. (2019). The morphogen Sonic hedgehog inhibits its receptor Patched by a pincer grasp mechanism. Nat. Chem. Biology, 15, 975-982